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Sophist icated methylat ion exper iment (1958) demonstrated that the most important Other curare alkaloids could be preparedįrom Strychnos alkaloids by photochemical oxidation (e.g. Alkaloids isolated from certain Strychnos species proved toīe identical with some of the curare alkaloids. Several observations facil i tated structure elucidat ion of the hith-Įrto unknown compounds. He separated this water-soluble mixture with newlyĭeveloped methodology (cellulose column, two dimensional paper chromatography) andĬharacterized the individual alkaloids mainly by their UV spectra and color react ions This muscle relaxant drug is a dark brownish Important contr ibutions in the field ofĪlkaloids began in 1945 (together with Paul Karrer) when he invest igated CalabashĬurare of the South American Indians. On the mechanist ic aspects of organic reactions. 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