![]() ![]() ![]() Including the determination of the absolute configuration of these natural products.ĭuring structural investigation of the spermidine alkaloid oncinotine, he observed a One of his special interests was the correlation of compounds by partial syntheses, ![]() ![]() Villalstonine was the first bisindole alkaloid whose structure was elucidated by species of the genera Alstonia,Īspidosperma, Conopharyngia, Gabunia, Hunteria, lboga, Oncinotis, Rauwolfia, Various apocynaceous plants were investigated (e.g. When NMR and mass spectrometry became available, a large number of alkaloids from Subsequently, the structures of most of the curare al. In 1958 he discovered that the Wei land-GumlichĪldehyde, a well known degradation product of strychnine, can be dimerized to give theĬurare alkaloid dihyrotoxiferine. Sophist icated methylat ion exper iment (1958) demonstrated that the most important Other curare alkaloids could be preparedįrom Strychnos alkaloids by photochemical oxidation (e.g. Alkaloids isolated from certain Strychnos species proved toīe identical with some of the curare alkaloids. Several observations facil i tated structure elucidat ion of the hith-Įrto unknown compounds. He separated this water-soluble mixture with newlyĭeveloped methodology (cellulose column, two dimensional paper chromatography) andĬharacterized the individual alkaloids mainly by their UV spectra and color react ions This muscle relaxant drug is a dark brownish Important contr ibutions in the field ofĪlkaloids began in 1945 (together with Paul Karrer) when he invest igated CalabashĬurare of the South American Indians. On the mechanist ic aspects of organic reactions. His scientific interest centered on the chemistry of organic natural products as well as ![]()
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